| Title |
Role of Viruses in the Development of Atopic Disease in Pediatric Patients
|
|---|---|
| Published in |
Current Allergy and Asthma Reports, August 2012
|
| DOI | 10.1007/s11882-012-0295-y |
| Pubmed ID | |
| Authors |
Dorothy S. Cheung, Mitchell H. Grayson |
| Abstract |
The prevalence of atopic diseases continues to rise in modernized countries, without a clear explanation for this increase. One potential cause identified from epidemiologic studies of children is respiratory RNA viral infections leading to development of recurrent wheezing, asthma, and allergic sensitization. We review human epidemiologic data that both support and refute the role of viruses in this process. Exploring recent murine models, we document possible immunologic mechanisms that could translate a viral infection into atopic disease. We further discuss evidence for a post-viral "atopic cycle" that could explain the development of multiple allergen sensitization, and we explore available data to suggest a connection between viral infections of the gastrointestinal tract with the development of food allergy. Taken together, this review documents evidence to support the "viral hypothesis", and, in particular, the role of RNA viruses in the development of atopic disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 5% |
| Australia | 1 | 3% |
| Unknown | 34 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 19% |
| Other | 5 | 14% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Bachelor | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Other | 9 | 24% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 43% |
| Immunology and Microbiology | 4 | 11% |
| Agricultural and Biological Sciences | 3 | 8% |
| Engineering | 2 | 5% |
| Nursing and Health Professions | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 8 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Current Allergy and Asthma Reports
#734
of 803 outputs
Outputs of similar age
#151,475
of 169,209 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#25
of 25 outputs
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