Title |
Exploring the Prevalence of Ten Polyomaviruses and Two Herpes Viruses in Breast Cancer
|
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Published in |
PLOS ONE, August 2012
|
DOI | 10.1371/journal.pone.0039842 |
Pubmed ID | |
Authors |
Annika Antonsson, Seweryn Bialasiewicz, Rebecca J. Rockett, Kevin Jacob, Ian C. Bennett, Theo P. Sloots |
Abstract |
Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, and TSV from the Polyomaviridae family in 54 fresh frozen breast tumour specimens. Relevant clinical data and basic lifestyle data were available for all patients. The tissue samples were DNA extracted and real-time PCR assays were used for viral detection.The highest prevalence, 10% (5/54), was found for EBV. MCV, HPyV6, and HPyV7 were detected in single patient samples (2% each), while WUV, KIV, JCV, BKV, LPV, SV40, TSV and CMV were not detected in the 54 breast cancer specimens analysed here. Further investigations are needed to elucidate the potential role of viruses, and particularly EBV, in breast carcinogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 18% |
Researcher | 7 | 18% |
Student > Master | 6 | 16% |
Student > Ph. D. Student | 4 | 11% |
Lecturer | 1 | 3% |
Other | 3 | 8% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 26% |
Medicine and Dentistry | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Immunology and Microbiology | 2 | 5% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 11 | 29% |