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Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins

Overview of attention for article published in Frontiers in Neuroscience, June 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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70 Mendeley
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Title
Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins
Published in
Frontiers in Neuroscience, June 2016
DOI 10.3389/fnins.2016.00311
Pubmed ID
Authors

Erica F. Diezmos, Paul P. Bertrand, Lu Liu

Abstract

Purinergic receptors play an important role in inflammation, and can be activated by ATP released via pannexin channels and/or connexin hemichannels. The purinergic P2X7 receptor (P2X7R) is of interest since it is involved in apoptosis when activated. Most studies focus on the influence of pannexin-1 (Panx1) and connexin 43 (Cx43) on ATP release and how it affects P2X7R function during inflammation. Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation within the gastrointestinal system. At present, the pathophysiology of this disease remains largely unknown but it may involve the interplay between P2X7R, Panx1, and Cx43. There are two main types of IBD, ulcerative colitis and Crohn's disease, that are classified by their location and frequency of inflammation. Current research suggests that alterations to normal functioning of innate and adaptive immunity may be a factor in disease progression. The involvement of purinergic receptors, connexins, and pannexins in IBD is a relatively novel notion in the context of gastrointestinal inflammation, and has been explored by various research groups. Thus, the present review focuses on the current research involving connexins, pannexins, and purinergic receptors within the gut and enteric nervous system, and will examine their involvement in inflammation and the pathophysiology of IBD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 30%
Student > Master 10 14%
Researcher 9 13%
Student > Bachelor 6 9%
Student > Doctoral Student 5 7%
Other 7 10%
Unknown 12 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 21%
Medicine and Dentistry 10 14%
Agricultural and Biological Sciences 10 14%
Neuroscience 8 11%
Immunology and Microbiology 6 9%
Other 9 13%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2016.
All research outputs
#7,688,662
of 25,374,647 outputs
Outputs from Frontiers in Neuroscience
#4,845
of 11,542 outputs
Outputs of similar age
#117,841
of 367,294 outputs
Outputs of similar age from Frontiers in Neuroscience
#71
of 156 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,294 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.