| Title |
Developmental cell death: morphological diversity and multiple mechanisms
|
|---|---|
| Published in |
Brain Structure and Function, March 1990
|
| DOI | 10.1007/bf00174615 |
| Pubmed ID | |
| Authors |
Peter G. H. Clarke |
| Abstract |
Physiological cell death is a widespread phenomenon in the development of both vertebrates and invertebrates. This review concentrates on an aspect of developmental cell death that has tended to be neglected, the manner in which the cells are dismantled. It is emphasized that the dying cells may adopt one of at least three different morphological types: "apoptotic", "autophagic", and "non-lysosomal vesiculate". These probably reflect a corresponding multiplicity of intracellular events. In particular, the destruction of the cytoplasm in these three types appears to be achieved primarily by heterophagy, by autophagy and by non-lysosomal degradation, respectively. The various mechanisms underlying both nuclear and cytoplasmic destruction are reviewed in detail. The multiplicity of destructive mechanisms needs to be born in mind in studies of other aspects of cell death such as the signals which trigger it, since different signals probably trigger different types of cell death. |
Mendeley readers
The data shown below were compiled from readership statistics for 284 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Spain | 2 | <1% |
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| Finland | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 274 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 25% |
| Student > Master | 37 | 13% |
| Researcher | 33 | 12% |
| Student > Bachelor | 29 | 10% |
| Student > Doctoral Student | 19 | 7% |
| Other | 49 | 17% |
| Unknown | 46 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 30% |
| Biochemistry, Genetics and Molecular Biology | 56 | 20% |
| Medicine and Dentistry | 25 | 9% |
| Neuroscience | 19 | 7% |
| Chemistry | 9 | 3% |
| Other | 32 | 11% |
| Unknown | 58 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Brain Structure and Function
#1,808
of 2,021 outputs
Outputs of similar age
#14,391
of 14,696 outputs
Outputs of similar age from Brain Structure and Function
#2
of 2 outputs
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