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Adenosine deaminase cutoff value when diagnosing tuberculous pleurisy in patients aged 40 years and older

Overview of attention for article published in Clinical Respiratory Journal, October 2020
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Title
Adenosine deaminase cutoff value when diagnosing tuberculous pleurisy in patients aged 40 years and older
Published in
Clinical Respiratory Journal, October 2020
DOI 10.1111/crj.13277
Pubmed ID
Authors

Burcu Arpinar Yigitbas, Celal Satici, A. Filiz Kosar

Abstract

Tuberculous pleurisy (TBP) is one of the most common manifestations of extra-pulmonary tuberculosis. In patients aged ≥40 years, a closed needle pleural biopsy is recommended with an adenosine deaminase (ADA) level of 40-70 U/L. We aim to investigate whether the cut-off value of ADA and the cancer ratio in patients with TBPaged ≥40 years is different and determine the effects of both compounded biomarkers on diagnosing TBP. Between 2009 and 2016, ADA levels were measured in pleural effusions from patients who were admitted to the Chest disease clinic. Of the196 patients included in the study, 104 were aged ≥40 years. A significant relationship was found between the serumLDH/pleuralADA(sLDH/pADA) ratio and ADA levels in patients aged >40 years (OR: 0.935 and OR: 1.085, respectively). The model using an ADA value ≥30 and an sLDH/pADA ratio <16 yielded a sensitivity of 94.25% (95% CI, 87.1-98.10) in all patients and 69.23% (95% CI, 54.9-81.28) in patients aged >40 years. ADA and the sLDH/pADA ratio are simple, cost-efficient, and obtain fast resultsand, therefore, are the preferred methods in TBP diagnosis. The diagnosis rate in the present study was 91% using ADA levels in combination withthesLDH/pADA ratio, both of which can be obtained only through thoracentesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 27%
Unspecified 1 9%
Student > Doctoral Student 1 9%
Unknown 6 55%
Readers by discipline Count As %
Unspecified 1 9%
Business, Management and Accounting 1 9%
Economics, Econometrics and Finance 1 9%
Energy 1 9%
Unknown 7 64%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2020.
All research outputs
#22,771,990
of 25,387,668 outputs
Outputs from Clinical Respiratory Journal
#581
of 764 outputs
Outputs of similar age
#375,416
of 434,595 outputs
Outputs of similar age from Clinical Respiratory Journal
#16
of 22 outputs
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