| Title |
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2010
|
| DOI | 10.1007/s00018-009-0242-9 |
| Pubmed ID | |
| Authors |
Ji-Won Jung, Seunghee Lee, Min-Soo Seo, Sang-Bum Park, Andreas Kurtz, Soo-Kyung Kang, Kyung-Sun Kang |
| Abstract |
Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro. Decreased expression of histone deacetylases (HDACs), followed by downregulation of polycomb group genes (PcGs), such as BMI1, EZH2 and SUZ12, and by upregulation of jumonji domain containing 3 (JMJD3), was observed in senescent MSCs. Similarly, HDAC inhibitors induced cellular senescence through downregulation of PcGs and upregulation of JMJD3. Regulation of PcGs was associated with HDAC inhibitor-induced hypophosphorylation of RB, which causes RB to bind to and decrease the transcriptional activity of E2F. JMJD3 expression regulation was dependant on histone acetylation status at its promoter regions. A histone acetyltransferase (HAT) inhibitor prevented replicative senescence of MSCs. These results suggest that HDAC activity might be important for MSC self-renewal by balancing PcGs and JMJD3 expression, which govern cellular senescence by p16(INK4A) regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Japan | 3 | 3% |
| Italy | 2 | 2% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Israel | 1 | <1% |
| China | 1 | <1% |
| Unknown | 103 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 35 | 30% |
| Student > Ph. D. Student | 25 | 22% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 7 | 6% |
| Professor > Associate Professor | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 12 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 45% |
| Medicine and Dentistry | 17 | 15% |
| Biochemistry, Genetics and Molecular Biology | 16 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Neuroscience | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 15 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#7,591,533
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,602
of 4,151 outputs
Outputs of similar age
#48,822
of 168,480 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 24 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,480 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.