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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Synthesis and biological evaluation of novel isoellipticine derivatives and salts
|
|---|---|
| Published in |
Organic and Biomolecular Chemistry, January 2012
|
| DOI | 10.1039/c2ob26181b |
| Pubmed ID | |
| Authors |
Charlotte M. Miller, Elaine C. O'Sullivan, Ken J. Devine, Florence O. McCarthy |
| Abstract |
Synthesis of novel 7-substituted isoellipticines and isoellipticinium salts is described, with optimisation of routes, representing a new class of anti-cancer agent. Initial assessment of biological activity using a topoisomerase II decatenation assay and NCI screening highlighted strong anti-cancer activity, further developed in a panel of isoellipticinium salts. Interestingly, low correlation between results of the topoisomerase II decatenation assay and NCI screen throughout the panel suggest that topo II is not the most important biological target with respect to anti-cancer activity in this new class of compounds. Results also suggest that solubility is not the limiting factor in activity of the isoellipticinium salts. Overall, 20 novel ellipticine analogues were prepared and full anti-cancer profiling was completed for 13 isoellipticine derivatives and salts. Two compounds display significant specificity towards CNS cancer cell lines and are lead compounds for future development. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 30% |
| Student > Doctoral Student | 2 | 20% |
| Student > Bachelor | 2 | 20% |
| Lecturer | 1 | 10% |
| Student > Master | 1 | 10% |
| Other | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 70% |
| Agricultural and Biological Sciences | 2 | 20% |
| Medicine and Dentistry | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2012.
All research outputs
#20,254,701
of 25,756,911 outputs
Outputs from Organic and Biomolecular Chemistry
#5,468
of 6,872 outputs
Outputs of similar age
#201,303
of 251,834 outputs
Outputs of similar age from Organic and Biomolecular Chemistry
#115
of 137 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,872 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,834 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.