| Title |
Motor sequence learning in the elderly: differential activity patterns as a function of hand modality
|
|---|---|
| Published in |
Brain Imaging and Behavior, July 2016
|
| DOI | 10.1007/s11682-016-9569-7 |
| Pubmed ID | |
| Authors |
Luis Eudave, Maite Aznárez-Sanado, Elkin O. Luis, Martín Martínez, María A. Fernández-Seara, María A. Pastor |
| Abstract |
Previous research on motor sequence learning (MSL) in the elderly has focused mainly on unilateral tasks, even though bilateral coordination might be impaired in this age group. In this fMRI study, 28 right-handed elderly subjects were recruited. The paradigm consisted of a Novel and a simple Control sequence executed with the right (R), left (L) and both hands (B). Behavioral performance (Accuracy[AC], Inter-tap Interval[ITI]) and associated brain activity were assessed during early learning. Behavioral performance in the Novel task was similar between unilateral conditions whereas in the bimanual condition more errors and slower motor execution were observed. Brain activity increases during learning showed differences between Conditions: R showed increased activity in pre-SMA, basal ganglia and left hippocampus while B showed activity increments mainly in posterior parietal cortex and cerebellum. L did not show any activity modulation during learning. Performance correlates for AC (related to spatial success) and ITI (related to accurate timing) shared a cortico-basal-cerebellar network. However, it was found that the ITI regressor presented additional significant correlations with activity in SMA and basal ganglia in R. The AC regressor showed additional significant correlations with activity in more extended thalamic and cerebellar areas in B. The present findings suggest that, behaviorally, the spatial and temporal components of MSL are impaired in elderly subjects when using both hands. Additionally, differential brain activity patterns were found across hand modalities. The results obtained reveal the existence of a highly specialized network in the dominant hand and identify areas specifically involved in bimanual coordination. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 42 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 16% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Bachelor | 5 | 12% |
| Student > Doctoral Student | 4 | 9% |
| Researcher | 4 | 9% |
| Other | 9 | 21% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 23% |
| Medicine and Dentistry | 5 | 12% |
| Psychology | 5 | 12% |
| Business, Management and Accounting | 2 | 5% |
| Nursing and Health Professions | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2016.
All research outputs
#15,379,760
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Outputs from Brain Imaging and Behavior
#671
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Outputs of similar age
#234,861
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Outputs of similar age from Brain Imaging and Behavior
#14
of 24 outputs
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