| Title |
Coming of age: the artificial pancreas for type 1 diabetes
|
|---|---|
| Published in |
Diabetologia, June 2016
|
| DOI | 10.1007/s00125-016-4022-4 |
| Pubmed ID | |
| Authors |
Hood Thabit, Roman Hovorka |
| Abstract |
The artificial pancreas (closed-loop system) addresses the unmet clinical need for improved glucose control whilst reducing the burden of diabetes self-care in type 1 diabetes. Glucose-responsive insulin delivery above and below a preset insulin amount informed by sensor glucose readings differentiates closed-loop systems from conventional, threshold-suspend and predictive-suspend insulin pump therapy. Insulin requirements in type 1 diabetes can vary between one-third-threefold on a daily basis. Closed-loop systems accommodate these variations and mitigate the risk of hypoglycaemia associated with tight glucose control. In this review we focus on the progress being made in the development and evaluation of closed-loop systems in outpatient settings. Randomised transitional studies have shown feasibility and efficacy of closed-loop systems under supervision or remote monitoring. Closed-loop application during free-living, unsupervised conditions by children, adolescents and adults compared with sensor-augmented pumps have shown improved glucose outcomes, reduced hypoglycaemia and positive user acceptance. Innovative approaches to enhance closed-loop performance are discussed and we also present the outlook and strategies used to ease clinical adoption of closed-loop systems. |
X Demographics
The data shown below were collected from the profiles of 81 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 16% |
| United Kingdom | 8 | 10% |
| Spain | 4 | 5% |
| Italy | 3 | 4% |
| Mexico | 3 | 4% |
| Germany | 2 | 2% |
| Australia | 2 | 2% |
| France | 2 | 2% |
| New Zealand | 2 | 2% |
| Other | 12 | 15% |
| Unknown | 30 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 54 | 67% |
| Scientists | 16 | 20% |
| Practitioners (doctors, other healthcare professionals) | 8 | 10% |
| Science communicators (journalists, bloggers, editors) | 3 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 273 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 56 | 20% |
| Student > Ph. D. Student | 40 | 15% |
| Researcher | 40 | 15% |
| Student > Master | 25 | 9% |
| Other | 16 | 6% |
| Other | 43 | 16% |
| Unknown | 54 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 23% |
| Engineering | 50 | 18% |
| Biochemistry, Genetics and Molecular Biology | 22 | 8% |
| Computer Science | 12 | 4% |
| Nursing and Health Professions | 9 | 3% |
| Other | 47 | 17% |
| Unknown | 72 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 386. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#80,964
of 25,732,188 outputs
Outputs from Diabetologia
#65
of 5,376 outputs
Outputs of similar age
#1,684
of 368,129 outputs
Outputs of similar age from Diabetologia
#4
of 82 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.8. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.