| Title |
Characterization of endometriosis-associated immune cell infiltrates (EMaICI)
|
|---|---|
| Published in |
Archives of Gynecology and Obstetrics, June 2016
|
| DOI | 10.1007/s00404-016-4142-6 |
| Pubmed ID | |
| Authors |
Claudia Scheerer, Petia Bauer, Vito Chiantera, Jalid Sehouli, Andreas Kaufmann, Sylvia Mechsner |
| Abstract |
To identify and characterize endometriosis-associated immune cell infiltrates (EMaICI). Furthermore, to define occurrence and size of EMaICI in various types of endometriosis. Immune cells were characterized in samples of 60 premenopausal women with histological proven endometriosis. Therefore, immunohistochemical staining with monoclonal antibodies for CD3, CD4, CD8, CD45RO, CD25, CD56, CD68, and CD20 on sections of paraffin-embedded endometriotic tissue was performed. EMaICI were observed in all the types of endometriosis, and characterized as T lymphocytes (CD3+), helper T lymphocytes (CD4+), cytotoxic T lymphocytes (CD8+), antigen-experienced T lymphocytes"memory cells" (CD45RO+), macrophages (CD68+), and B lymphocytes (CD20+). The maximum frequency of EMaICI and their distribution per endometriotic lesion (EML) was observed in peritoneal endometriosis (pEM) and in ovarian endometriosis (Ov. EM). In myometrium from adenomyosis (M/AM), EMaICI occurrence was lower and smaller in size in comparison with EMaICI seen in other forms of endometriosis. EMaICI were negative for regulatory T cells (CD25+ high, FoxP3+) and natural killer cells (NK cells, CD56+). Numerous and brisk EMaICI comprising several types of immune cells in all endometriosis forms suggest acute immunological reactions within the microenvironment of endometriosis lesions. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 15% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 6 | 10% |
| Researcher | 5 | 8% |
| Other | 13 | 21% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Immunology and Microbiology | 6 | 10% |
| Agricultural and Biological Sciences | 5 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 20 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2016.
All research outputs
#21,164,509
of 23,815,455 outputs
Outputs from Archives of Gynecology and Obstetrics
#1,537
of 2,066 outputs
Outputs of similar age
#309,038
of 355,422 outputs
Outputs of similar age from Archives of Gynecology and Obstetrics
#19
of 25 outputs
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