| Title |
Candida utilis and Cyberlindnera (Pichia) jadinii: yeast relatives with expanding applications
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, June 2016
|
| DOI | 10.1007/s00253-016-7700-8 |
| Pubmed ID | |
| Authors |
Christoph Buerth, Denis Tielker, Joachim F. Ernst |
| Abstract |
The yeast Candida utilis is used as a food additive and as a host for heterologous gene expression to produce various metabolites and proteins. Reliable protocols for intracellular production of recombinant proteins are available for C. utilis and have now been expanded to secrete proteins into the growth medium or to achieve surface display by linkage to a cell wall protein. A recombinant C. utilis strain was recently shown to induce oral tolerance in a mouse model of multiple sclerosis suggesting future applications in autoimmune therapy. Whole genome sequencing of C. utilis and its presumed parent Cyberlindnera (Pichia) jadinii demonstrated different ploidy but high sequence identity, consistent with identical recombinant technologies for both yeasts. C. jadinii was recently described as an antagonist to the important human fungal pathogen Candida albicans suggesting its use as a probiotic agent. The review summarizes the status of recombinant protein production in C. utilis, as well as current and future biotechnological and medical applications of C. utilis and C. jadinii. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 16% |
| Researcher | 18 | 14% |
| Student > Ph. D. Student | 14 | 11% |
| Student > Bachelor | 13 | 10% |
| Other | 8 | 6% |
| Other | 14 | 11% |
| Unknown | 40 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 21% |
| Biochemistry, Genetics and Molecular Biology | 23 | 18% |
| Medicine and Dentistry | 9 | 7% |
| Engineering | 5 | 4% |
| Chemical Engineering | 4 | 3% |
| Other | 15 | 12% |
| Unknown | 44 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#3,024,810
of 24,727,020 outputs
Outputs from Applied Microbiology and Biotechnology
#432
of 8,149 outputs
Outputs of similar age
#52,077
of 359,296 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#7
of 117 outputs
Altmetric has tracked 24,727,020 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,149 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.