| Title |
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring
|
|---|---|
| Published in |
GeroScience, August 2012
|
| DOI | 10.1007/s11357-012-9463-1 |
| Pubmed ID | |
| Authors |
Davide Gentilini, Daniela Mari, Davide Castaldi, Daniel Remondini, Giulia Ogliari, Rita Ostan, Laura Bucci, Silvia M. Sirchia, Silvia Tabano, Francesco Cavagnini, Daniela Monti, Claudio Franceschi, Anna Maria Di Blasio, Giovanni Vitale |
| Abstract |
The role of epigenetics in the modulation of longevity has not been studied in humans. To this aim, (1) we evaluated the DNA methylation from peripheral leukocytes of 21 female centenarians, their 21 female offspring, 21 offspring of both non-long-lived parents, and 21 young women through ELISA assay, pyrosequencing analysis of Alu sequences, and quantification of methylation in CpG repeats outside CpG islands; (2) we compared the DNA methylation profiles of these populations through Infinium array for genome-wide CpG methylation analysis. We observed an age-related decrease in global DNA methylation and a delay of this process in centenarians' offspring. Interestingly, literature data suggest a link between the loss of DNA methylation observed during aging and the development of age-associated diseases. Genome-wide methylation analysis evidenced DNA methylation profiles specific for aging and longevity: (1) aging-associated DNA hypermethylation occurs predominantly in genes involved in the development of anatomical structures, organs, and multicellular organisms and in the regulation of transcription; (2) genes involved in nucleotide biosynthesis, metabolism, and control of signal transmission are differently methylated between centenarians' offspring and offspring of both non-long-lived parents, hypothesizing a role for these genes in human longevity. Our results suggest that a better preservation of DNA methylation status, a slower cell growing/metabolism, and a better control in signal transmission through epigenetic mechanisms may be involved in the process of human longevity. These data fit well with the observations related to the beneficial effects of mild hypothyroidism and insulin-like growth factor I system impairment on the modulation of human lifespan. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Czechia | 1 | 13% |
| Italy | 1 | 13% |
| United Kingdom | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 4 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Uruguay | 1 | <1% |
| New Zealand | 1 | <1% |
| Spain | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 204 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 20% |
| Student > Ph. D. Student | 38 | 18% |
| Student > Bachelor | 29 | 14% |
| Student > Master | 23 | 11% |
| Student > Doctoral Student | 16 | 7% |
| Other | 37 | 17% |
| Unknown | 28 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 25% |
| Biochemistry, Genetics and Molecular Biology | 53 | 25% |
| Medicine and Dentistry | 36 | 17% |
| Neuroscience | 5 | 2% |
| Psychology | 4 | 2% |
| Other | 26 | 12% |
| Unknown | 37 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2021.
All research outputs
#1,377,548
of 25,371,288 outputs
Outputs from GeroScience
#156
of 1,594 outputs
Outputs of similar age
#8,110
of 186,839 outputs
Outputs of similar age from GeroScience
#1
of 15 outputs
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