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Timing of allergy‐preventive and immunomodulatory dietary interventions – are prenatal, perinatal or postnatal strategies optimal?

Overview of attention for article published in Clinical & Experimental Allergy, February 2013
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Title
Timing of allergy‐preventive and immunomodulatory dietary interventions – are prenatal, perinatal or postnatal strategies optimal?
Published in
Clinical & Experimental Allergy, February 2013
DOI 10.1111/cea.12003
Pubmed ID
Authors

M. C. Jenmalm, K. Duchén

Abstract

The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation and a decreased dietary ω-3/ω-6 long-chain polyunsaturated fatty acid (LCPUFA) ratio, resulting in an abnormal postnatal immune maturation. The timing of allergy-preventive probiotic and ω-3 LCPUFA interventions is critical, as early-life events occurring during critical windows of immune vulnerability can have long-term impact on immune development. The maternal dietary and microbial environment during pregnancy may programme the immune development of the child. Prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment, but potentially also increasing disease susceptibility in the offspring if exposures are mismatched. Although the importance of fetal programming mostly has been studied in cardiovascular and metabolic disease, this hypothesis is also very attractive in the context of environmentally influenced immune-mediated diseases. This review focuses on how prenatal, perinatal or postnatal ω-3 LCPUFA interventions regulate childhood immune and allergy development, and if synergistic effects may be obtained by simultaneous probiotic supplementation. We propose that combined pre- and postnatal preventive measures may be most efficacious. Increasing knowledge on the immunomodulatory effects of prenatal, perinatal and postnatal interventions will help to direct future strategies to combat the allergy epidemic.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 17%
Student > Ph. D. Student 13 16%
Student > Master 10 12%
Researcher 9 11%
Other 5 6%
Other 18 22%
Unknown 12 15%
Readers by discipline Count As %
Medicine and Dentistry 30 37%
Agricultural and Biological Sciences 14 17%
Biochemistry, Genetics and Molecular Biology 5 6%
Immunology and Microbiology 4 5%
Nursing and Health Professions 4 5%
Other 9 11%
Unknown 15 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2013.
All research outputs
#15,687,538
of 24,851,605 outputs
Outputs from Clinical & Experimental Allergy
#3,071
of 3,800 outputs
Outputs of similar age
#115,382
of 196,397 outputs
Outputs of similar age from Clinical & Experimental Allergy
#26
of 40 outputs
Altmetric has tracked 24,851,605 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,800 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,397 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.