| Title |
Biological Functions and Metabolism of Oleoylethanolamide
|
|---|---|
| Published in |
Lipids, August 2008
|
| DOI | 10.1007/s11745-008-3217-y |
| Pubmed ID | |
| Authors |
Clémentine Thabuis, Delphine Tissot‐Favre, Jean‐Baptiste Bezelgues, Jean‐Charles Martin, Cristina Cruz‐Hernandez, Fabiola Dionisi, Frédéric Destaillats |
| Abstract |
The present review is focused on the metabolism and the emerging roles of oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid metabolism. The biological mechanism of action, including a non-genomic effect mediated through peroxisome proliferator-activated receptor alpha (PPAR-alpha) and transient receptor potential vanilloid type 1 (TRPV1) receptor, is discussed. The research related to fatty acid ethanolamides has been focused until recently on anandamide and its interaction with cannabinoid receptor subtype 1. The roles of other N-acyl ethanolamine fatty acid derivatives have been neglected until it was demonstrated that OEA can modulate food intake control through interaction with PPAR-alpha. Further investigations demonstrated that OEA modulates lipid and glucose metabolism, and recent study confirmed that OEA is an antagonist of TRVP1. It has been demonstrated that OEA has beneficial effects on health by inducing food intake control, lipid beta-oxidation, body weight loss and analgesic effects. The investigation of the mechanism of action revealed that OEA activates PPAR-alpha and stimulates the vagal nerve through the capsaicin receptor TRPV1. Pre-clinical studies showed that OEA remains active when administered orally. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 98 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 18% |
| Researcher | 16 | 16% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 8 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Other | 17 | 17% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 23% |
| Medicine and Dentistry | 16 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Chemistry | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 29 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2016.
All research outputs
#15,379,760
of 22,880,230 outputs
Outputs from Lipids
#1,542
of 1,904 outputs
Outputs of similar age
#69,981
of 82,374 outputs
Outputs of similar age from Lipids
#11
of 12 outputs
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.