| Title |
Immunohistochemical markers of advanced basal cell carcinoma: CD56 is associated with a lack of response to vismodegib
|
|---|---|
| Published in |
European Journal of Dermatology, November 2016
|
| DOI | 10.1684/ejd.2016.2826 |
| Pubmed ID | |
| Authors |
Jean-Marie Castillo, Anne-Chantal Knol, Jean-Michel Nguyen, Amir Khammari, Mélanie Saint-Jean, Brigitte Dreno |
| Abstract |
Vismodegib is an effective treatment for advanced basal cell carcinoma (BCC), but primary resistance to vismodegib remains to be elucidated. Alternative approaches may be warranted to help better select patients who are most likely to be responsive to treatment. The identification of immuno-histochemical markers may support this perspective, as well as a better understanding of resistance mechanisms. To determine the level of expression of CD56, PDGF-Rα, CD117, MMP9, TIMP3, and CXCR4 in advanced BCC, and explore whether expression levels are associated with a lack of response to vismodegib. A cross-sectional study was conducted. Immuno-histochemical markers were selected based on their roles in tumour proliferation and/or migration in BCC or skin tumours. Expression was evaluated on a 5-point scale. Tissue samples included were pre-treatment advanced BCC samples from patients treated with vismodegib, with an available response after six months of treatment. Regression optimised models were used to build hypotheses regarding a possible association between expression levels and a lack of response to vismodegib, which was then tested by logistic regression. Twenty-three patients were included. The percentage of samples expressing markers ranged from 43.5% for CD117 to 91.3% for CXCR4. CD56 expression was significantly associated with an increased risk of lack of response to vismodegib (OR = 5.5; CI 95%: 3.4-29.8; p = 0.0488); a similar association was suggested for CXCR4 (p = 0.066), but not identified for other markers. These results provide us with a better understanding of the expression of immuno-histochemical markers in advanced BCC. A further detailed analysis of CD56 expression may provide insights into guiding further investigation of the correlation between this marker and a lack of response to vismodegib. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 18% |
| Student > Doctoral Student | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Student > Master | 1 | 6% |
| Researcher | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 8 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 29% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Unknown | 9 | 53% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2016.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from European Journal of Dermatology
#472
of 720 outputs
Outputs of similar age
#246,095
of 319,134 outputs
Outputs of similar age from European Journal of Dermatology
#7
of 9 outputs
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