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Renal biopsy findings among Indigenous Australians: a nationwide review

Overview of attention for article published in Kidney International, August 2012
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Title
Renal biopsy findings among Indigenous Australians: a nationwide review
Published in
Kidney International, August 2012
DOI 10.1038/ki.2012.307
Pubmed ID
Authors

Wendy E. Hoy, Terence Samuel, Susan A. Mott, Priscilla S. Kincaid-Smith, Agnes B. Fogo, John P. Dowling, Michael D. Hughson, Rajalingam Sinniah, David J. Pugsley, Meshach G. Kirubakaran, Rebecca N. Douglas-Denton, John F. Bertram

Abstract

Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathological findings and terminology, quantify glomerular size, and establish and compare regional biopsy profiles. The relative population-adjusted biopsy frequencies were 16.9, 6.6, and 1, respectively, for Aboriginal people living remotely/very remotely, for Torres Strait Islander people, and for non-remote-living Aboriginal people. Indigenous people more often had heavy proteinuria and renal failure at biopsy. No single condition defined the Indigenous biopsies and, where biopsy rates were high, all common conditions were in absolute excess. Indigenous people were more often diabetic than non-Indigenous people, but diabetic changes were still present in fewer than half their biopsies. Their biopsies also had higher rates of segmental sclerosis, post-infectious glomerulonephritis, and mixed morphologies. Among the great excess of biopsies in remote/very remote Aborigines, females predominated, with younger age at biopsy and larger mean glomerular volumes. Glomerulomegaly characterized biopsies with mesangiopathic changes only, with IgA deposition, or with diabetic change, and with focal segmental glomerulosclerosis (FSGS). This review reveals great variations in biopsy rates and findings among Indigenous Australians, and findings refute the prevailing dogma that most indigenous renal disease is due to diabetes. Glomerulomegaly in remote/very remote Aboriginal people is probably due to nephron deficiency, in part related to low birth weight, and probably contributes to the increased susceptibility to kidney disease and the predisposition to FSGS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 18%
Student > Ph. D. Student 7 12%
Student > Master 5 9%
Student > Postgraduate 5 9%
Professor 5 9%
Other 12 21%
Unknown 13 23%
Readers by discipline Count As %
Medicine and Dentistry 21 37%
Nursing and Health Professions 7 12%
Psychology 5 9%
Agricultural and Biological Sciences 4 7%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 4 7%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2012.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Kidney International
#6,189
of 7,405 outputs
Outputs of similar age
#125,041
of 187,950 outputs
Outputs of similar age from Kidney International
#30
of 52 outputs
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