| Title |
The role of apelin in the healing of water-immersion and restraint stress-induced gastric damage
|
|---|---|
| Published in |
The Journal of Physiological Sciences, July 2016
|
| DOI | 10.1007/s12576-016-0469-9 |
| Pubmed ID | |
| Authors |
İlknur Birsen, Burcu Gemici, Nuray Acar, İsmail Üstünel, V. Nimet İzgüt-Uysal |
| Abstract |
The objective of this study was to explore the role of apelin in the healing of gastric lesions induced by stress. Male Wistar rats were exposed to water immersion and restraint stress (WIRS) for 6 h with or without the apelin receptor antagonist F13A. The rats were killed on the 1st, 3rd, 5th or 10th day after the end of stress induction. Apelin and hypoxia-inducible factor-1α expression was increased on the 1st day after the end of stress exposure and was decreased daily thereafter. However, F13A retarded the healing of gastric lesions by preventing the improvement of mucosal blood flow, prostaglandin E2 production and vascular endothelial growth factor expression in rats exposed to WIRS. Additionally, F13A increased the gastric 4-hydroxynonenol + malondialdehyde content on the 1st and 3rd days after the end of stress induction but did not affect the change in gastric mucosal nitric oxide levels. In conclusion, apelin may be a regulatory protein involved in the healing mechanism of stress-induced gastric damage. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 33% |
| Professor > Associate Professor | 2 | 17% |
| Student > Ph. D. Student | 1 | 8% |
| Researcher | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 33% |
| Nursing and Health Professions | 1 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Neuroscience | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2016.
All research outputs
#19,495,804
of 23,975,976 outputs
Outputs from The Journal of Physiological Sciences
#221
of 321 outputs
Outputs of similar age
#274,538
of 357,248 outputs
Outputs of similar age from The Journal of Physiological Sciences
#8
of 11 outputs
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