Title |
Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy
|
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Published in |
Gastroenterology, April 2012
|
DOI | 10.1053/j.gastro.2012.04.045 |
Pubmed ID | |
Authors |
Daniel Kotlarz, Rita Beier, Dhaarini Murugan, Jana Diestelhorst, Ole Jensen, Kaan Boztug, Dietmar Pfeifer, Hans Kreipe, Eva–Doreen Pfister, Ulrich Baumann, Jacek Puchalka, Jens Bohne, Odul Egritas, Buket Dalgic, Kaija–Leena Kolho, Axel Sauerbrey, Stephan Buderus, Tayfun Güngör, Axel Enninger, Yu Kar Ling Koda, Graziella Guariso, Batia Weiss, Selim Corbacioglu, Piotr Socha, Nuray Uslu, Ayse Metin, Ghassan T. Wahbeh, Khalid Husain, Dina Ramadan, Waleed Al–Herz, Bodo Grimbacher, Martin Sauer, Karl–Walter Sykora, Sibylle Koletzko, Christoph Klein |
Abstract |
Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD). Allogeneic hematopoietic stem cell transplantation (HSCT) was reported to induce sustained remission in 1 patient with IL-10R deficiency. We investigated heterogeneity among patients with very early onset IBD, its mechanisms, and the use of allogeneic HSCT to treat this disorder. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | <1% |
Australia | 1 | <1% |
Unknown | 238 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 55 | 23% |
Researcher | 41 | 17% |
Student > Master | 30 | 13% |
Student > Doctoral Student | 16 | 7% |
Student > Bachelor | 16 | 7% |
Other | 40 | 17% |
Unknown | 42 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 76 | 32% |
Agricultural and Biological Sciences | 40 | 17% |
Immunology and Microbiology | 28 | 12% |
Biochemistry, Genetics and Molecular Biology | 27 | 11% |
Psychology | 5 | 2% |
Other | 18 | 8% |
Unknown | 46 | 19% |