| Title |
Curcumin: From ancient medicine to current clinical trials
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2008
|
| DOI | 10.1007/s00018-008-7452-4 |
| Pubmed ID | |
| Authors |
H. Hatcher, R. Planalp, J. Cho, F. M. Torti, S. V. Torti |
| Abstract |
Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kappaB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro- and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 18% |
| Japan | 2 | 12% |
| United Kingdom | 2 | 12% |
| Ireland | 1 | 6% |
| Unknown | 9 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 94% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| India | 2 | <1% |
| Indonesia | 1 | <1% |
| Italy | 1 | <1% |
| Malaysia | 1 | <1% |
| French Polynesia | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 1102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 168 | 15% |
| Student > Master | 163 | 15% |
| Student > Ph. D. Student | 150 | 13% |
| Researcher | 96 | 9% |
| Student > Doctoral Student | 58 | 5% |
| Other | 206 | 18% |
| Unknown | 273 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 138 | 12% |
| Medicine and Dentistry | 136 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 116 | 10% |
| Biochemistry, Genetics and Molecular Biology | 107 | 10% |
| Chemistry | 105 | 9% |
| Other | 188 | 17% |
| Unknown | 324 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#733,594
of 25,416,581 outputs
Outputs from Cellular and Molecular Life Sciences
#56
of 5,887 outputs
Outputs of similar age
#1,416
of 94,672 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 35 outputs
Altmetric has tracked 25,416,581 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,887 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.