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A Census of Human Soluble Protein Complexes

Overview of attention for article published in Cell, August 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

blogs
2 blogs
twitter
20 X users
patent
12 patents
wikipedia
1 Wikipedia page
f1000
1 research highlight platform

Citations

dimensions_citation
753 Dimensions

Readers on

mendeley
1106 Mendeley
citeulike
15 CiteULike
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Title
A Census of Human Soluble Protein Complexes
Published in
Cell, August 2012
DOI 10.1016/j.cell.2012.08.011
Pubmed ID
Authors

Pierre C. Havugimana, G. Traver Hart, Tamás Nepusz, Haixuan Yang, Andrei L. Turinsky, Zhihua Li, Peggy I. Wang, Daniel R. Boutz, Vincent Fong, Sadhna Phanse, Mohan Babu, Stephanie A. Craig, Pingzhao Hu, Cuihong Wan, James Vlasblom, Vaqaar-un-Nisa Dar, Alexandr Bezginov, Gregory W. Clark, Gabriel C. Wu, Shoshana J. Wodak, Elisabeth R.M. Tillier, Alberto Paccanaro, Edward M. Marcotte, Andrew Emili

Abstract

Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, to systematically identify a network of 13,993 high-confidence physical interactions among 3,006 stably associated soluble human proteins. Most of the 622 putative protein complexes we report are linked to core biological processes and encompass both candidate disease genes and unannotated proteins to inform on mechanism. Strikingly, whereas larger multiprotein assemblies tend to be more extensively annotated and evolutionarily conserved, human protein complexes with five or fewer subunits are far more likely to be functionally unannotated or restricted to vertebrates, suggesting more recent functional innovations.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 29 3%
Germany 10 <1%
France 9 <1%
United Kingdom 9 <1%
Canada 8 <1%
Denmark 4 <1%
Italy 3 <1%
Korea, Republic of 2 <1%
Brazil 2 <1%
Other 18 2%
Unknown 1012 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 301 27%
Student > Ph. D. Student 295 27%
Student > Master 88 8%
Student > Bachelor 69 6%
Professor 55 5%
Other 189 17%
Unknown 109 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 493 45%
Biochemistry, Genetics and Molecular Biology 296 27%
Medicine and Dentistry 50 5%
Chemistry 41 4%
Computer Science 27 2%
Other 67 6%
Unknown 132 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#1,132,478
of 25,371,288 outputs
Outputs from Cell
#4,074
of 17,169 outputs
Outputs of similar age
#6,211
of 179,162 outputs
Outputs of similar age from Cell
#24
of 140 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,162 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.