Title |
Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives
|
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Published in |
Journal of Natural Medicines, July 2016
|
DOI | 10.1007/s11418-016-1020-2 |
Pubmed ID | |
Authors |
Megan M. Marlow, Sumedh S. Shah, Eduardo A. Véliz, Michael E. Ivan, Regina M. Graham |
Abstract |
Resistance mechanisms employed by high-grade gliomas allow them to successfully evade current standard treatment of chemotherapy and radiation treatment. Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its antitumor capabilities. Here we review pertinent literature on WA as a high-grade glioma treatment, and discuss the cancerous mechanisms it affects. WA is relatively nontoxic and has shown potential in crossing the blood-brain barrier. WA prevents p53 alterations and inactivates overexpressed MDM2 through ARF and ROS production. Furthermore, WA upregulates Bax, inducing mitochondrial death cascades, inhibits mutated Akt, mTOR, and NF-κB pathways, and inhibits angiogenesis in tumors. Therapy with WA for high-grade gliomas is supported through the literature. Further investigation is warranted and encouraged to fully unearth its abilities against malignant gliomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Portugal | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 22% |
Professor > Associate Professor | 5 | 14% |
Other | 4 | 11% |
Researcher | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Other | 7 | 19% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 42% |
Agricultural and Biological Sciences | 5 | 14% |
Neuroscience | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 7 | 19% |