| Title |
Oxidative stress in fibromyalgia and its relationship to symptoms
|
|---|---|
| Published in |
Clinical Rheumatology, December 2008
|
| DOI | 10.1007/s10067-008-1072-0 |
| Pubmed ID | |
| Authors |
Cecilia P. Chung, Dina Titova, Annette Oeser, Margaret Randels, Ingrid Avalos, Ginger L. Milne, Jason D. Morrow, C. Michael Stein |
| Abstract |
Oxidative stress is thought to play a role in the pathogenesis of fibromyalgia. We examined the hypothesis that oxidative stress was increased in patients with fibromyalgia and related to the severity of symptoms. Urinary F(2)-isoprostane excretion was measured in 48 patients with fibromyalgia and compared to those of 96 control subjects. In patients, we examined the association between oxidative stress and symptoms. Patients with fibromyalgia were significantly more symptomatic than control subjects, but urinary F(2)-isoprostane excretion did not differ significantly (2.3+/-1.9 vs. 2.8+/-2.2 ng/mg creatinine, p=0.16). In patients with fibromyalgia, F(2)-isoprostane excretion was associated with fatigue visual analog scale (rho=0.30, p=0.04) but not with pain, quality of life, functional capacity, depression, number of tender points, or overall impact of fibromyalgia. Oxidative stress is not increased in patients with fibromyalgia, but as was previously found in patients with systemic lupus erythematosus, oxidative stress was associated with fatigue. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 65 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 25% |
| Student > Master | 10 | 15% |
| Student > Doctoral Student | 6 | 9% |
| Researcher | 6 | 9% |
| Other | 5 | 7% |
| Other | 11 | 16% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 28% |
| Agricultural and Biological Sciences | 7 | 10% |
| Sports and Recreations | 6 | 9% |
| Psychology | 5 | 7% |
| Nursing and Health Professions | 5 | 7% |
| Other | 12 | 18% |
| Unknown | 14 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2013.
All research outputs
#18,313,878
of 22,675,759 outputs
Outputs from Clinical Rheumatology
#2,300
of 2,979 outputs
Outputs of similar age
#143,898
of 154,359 outputs
Outputs of similar age from Clinical Rheumatology
#11
of 12 outputs
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.