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Mendeley readers
Attention Score in Context
| Title |
Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis
|
|---|---|
| Published in |
Stem Cell Reports, June 2016
|
| DOI | 10.1016/j.stemcr.2016.06.002 |
| Pubmed ID | |
| Authors |
Talia Velasco-Hernandez, Petter Säwén, David Bryder, Jörg Cammenga |
| Abstract |
Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used "deleter strain" in experimental hematology. However, different pitfalls associated with this system could lead to misinterpretation in functional studies. We present here two of these issues related to the use of Mx1-Cre: first, a high spontaneous recombination rate when applying commonly used techniques in experimental hematology, and second, undesired short-term consequences of the use of polyinosinic:polycytidylic acid, including changes in cellular phenotypes that, however, resolve within days. Our studies emphasize therefore that proper controls are crucial when modeling gene deletion using the Mx1-Cre transgene. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 28% |
| Researcher | 34 | 21% |
| Student > Bachelor | 14 | 8% |
| Student > Master | 14 | 8% |
| Student > Doctoral Student | 9 | 5% |
| Other | 15 | 9% |
| Unknown | 33 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 58 | 35% |
| Agricultural and Biological Sciences | 26 | 16% |
| Medicine and Dentistry | 24 | 15% |
| Immunology and Microbiology | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 2 | 1% |
| Unknown | 35 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Stem Cell Reports
#2,010
of 2,142 outputs
Outputs of similar age
#283,177
of 366,920 outputs
Outputs of similar age from Stem Cell Reports
#35
of 40 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,142 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.