| Title |
The severity of ventricular arrhythmia correlates with the extent of myocardial sympathetic denervation, but not with myocardial fibrosis extent in chronic Chagas cardiomyopathy Chagas disease, denervation and arrhythmia
|
|---|---|
| Published in |
Journal of Nuclear Cardiology, July 2016
|
| DOI | 10.1007/s12350-016-0556-6 |
| Pubmed ID | |
| Authors |
Leonardo Pippa Gadioli, Carlos Henrique Miranda, Antonio Osvaldo Pintya, Alexandre Baldini de Figueiredo, André Schmidt, Benedito Carlos Maciel, José Antonio Marin-Neto, Marcus Vinicius Simões |
| Abstract |
To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥ 35% were divided into three groups: SVT group-presenting Sustained Ventricular Tachycardia (SVT) (n = 15), NSVT group-exhibiting episodes of non-SVT (NSVT) on 24-h Holter monitoring (n = 11), and Control group-exhibiting neither SVT nor episodes of NSVT (n = 17). The patients underwent SPECT imaging for myocardial sympathetic innervation with (123)Iodine-MIBG (MIBG) and myocardial perfusion with (99m)Tc-Sestamibi (MIBI) for the evaluation of regional myocardial fibrosis. The summed rest perfusion scores were similar in the three groups. The summed difference score between MIBG and MPI images, which evaluated the extent of denervated but viable myocardium, was significantly higher in SVT group (20.0 ± 8.0) as compared with the control group (2.0 ± 5.0, P < .0001) and with the NSVT group (11.0 ± 8.0, P < .05). The occurrence of ventricular arrhythmias of different degrees of severity correlates quantitatively with the extent of cardiac sympathetic denervation, but not with the extent of fibrosis, suggesting that myocardial sympathetic denervation plays a major role in triggering ventricular arrhythmia in CCC. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Saudi Arabia | 1 | 20% |
| Argentina | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 16% |
| Student > Postgraduate | 4 | 11% |
| Student > Master | 3 | 8% |
| Researcher | 3 | 8% |
| Professor | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 15 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 37% |
| Immunology and Microbiology | 3 | 8% |
| Agricultural and Biological Sciences | 1 | 3% |
| Computer Science | 1 | 3% |
| Sports and Recreations | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 15 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2016.
All research outputs
#15,755,393
of 25,394,764 outputs
Outputs from Journal of Nuclear Cardiology
#1,043
of 2,045 outputs
Outputs of similar age
#213,430
of 370,549 outputs
Outputs of similar age from Journal of Nuclear Cardiology
#21
of 63 outputs
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