Title |
Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration
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Published in |
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, August 2012
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DOI | 10.3109/17482968.2012.701308 |
Pubmed ID | |
Authors |
Julien Cohen-Adad, Mohamed-Mounir El Mendili, Régine Morizot-Koutlidis, Stéphane Lehéricy, Vincent Meininger, Sophie Blancho, Serge Rossignol, Habib Benali, Pierre-François Pradat |
Abstract |
Our objective was to demonstrate that ALS patients have sensory pathway involvement and that local cord atrophy reflects segmental lower motor neuron involvement. Twenty-nine ALS patients with spinal onset and twenty-one healthy controls were recruited. Diffusion tensor imaging (DTI), magnetization transfer and atrophy index were measured in the spinal cord, complemented with transcranial magnetic stimulations. Metrics were quantified within the lateral corticospinal and the dorsal segments of the cervical cord. Significant differences were detected between patients and controls for DTI and magnetization transfer metrics in the lateral and dorsal segments of the spinal cord. Fractional anisotropy correlated with ALSFRS-R (p = 0.04) and motor threshold (p = 0.02). Stepwise linear regression detected local spinal cord atrophy associated with weakness in the corresponding muscle territory, i.e. C4 level for deltoid and C7 level for hand muscles. In conclusion, impairment of spinal sensory pathways was detected at an early stage of the disease. Our data also demonstrate an association between muscle deficits and local spinal cord atrophy, suggesting that atrophy is a sensitive biomarker for lower motor neurons degeneration. |
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Mendeley readers
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Researcher | 11 | 12% |
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Student > Bachelor | 7 | 8% |
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