Title |
Significant variations in alternative splicing patterns and expression profiles between human-mouse orthologs in early embryos
|
---|---|
Published in |
Science China Life Sciences, July 2016
|
DOI | 10.1007/s11427-015-0348-5 |
Pubmed ID | |
Authors |
Geng Chen, Jiwei Chen, Jianmin Yang, Long Chen, Xiongfei Qu, Caiping Shi, Baitang Ning, Leming Shi, Weida Tong, Yongxiang Zhao, Meixia Zhang, Tieliu Shi |
Abstract |
Human and mouse orthologs are expected to have similar biological functions; however, many discrepancies have also been reported. We systematically compared human and mouse orthologs in terms of alternative splicing patterns and expression profiles. Human-mouse orthologs are divergent in alternative splicing, as human orthologs could generally encode more isoforms than their mouse orthologs. In early embryos, exon skipping is far more common with human orthologs, whereas constitutive exons are more prevalent with mouse orthologs. This may correlate with divergence in expression of splicing regulators. Orthologous expression similarities are different in distinct embryonic stages, with the highest in morula. Expression differences for orthologous transcription factor genes could play an important role in orthologous expression discordance. We further detected largely orthologous divergence in differential expression between distinct embryonic stages. Collectively, our study uncovers significant orthologous divergence from multiple aspects, which may result in functional differences and dynamics between human-mouse orthologs during embryonic development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 21% |
Student > Master | 3 | 16% |
Student > Bachelor | 2 | 11% |
Lecturer > Senior Lecturer | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Agricultural and Biological Sciences | 3 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Physics and Astronomy | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 37% |