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Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis

Overview of attention for article published in Molecular & Cellular Probes, August 2012
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Title
Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis
Published in
Molecular & Cellular Probes, August 2012
DOI 10.1016/j.mcp.2012.08.005
Pubmed ID
Authors

Geoffrey N. Gobert, Hong You, Malcolm K. Jones, Russell McInnes, Donald P. McManus

Abstract

The Chinese (SjC) and Philippine (SjP) strains of the blood fluke Schistosoma japonicum have been shown to present clearly different phenotypes in fecundity, pathology, drug sensitivity and immunology. We used microarray based comparative genomic hybridisation (aCGH) to investigate structural differences in the genomes of the two strains and identified seven distinct regions of the S. japonicum genome that present differential aCGH representing either deletion or duplication regions in SjP. Within these regions, genes predicted to be associated with the recognised phenotypic differences were identified and that may provide new insights into the biology and evolution of the two strains, with implications for the epidemiology and control of schistosomiasis japonica in China and the Philippines.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 17%
Lecturer 2 11%
Student > Bachelor 2 11%
Other 2 11%
Student > Master 2 11%
Other 4 22%
Unknown 3 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 22%
Immunology and Microbiology 3 17%
Engineering 2 11%
Medicine and Dentistry 2 11%
Veterinary Science and Veterinary Medicine 1 6%
Other 1 6%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2012.
All research outputs
#20,723,696
of 25,457,297 outputs
Outputs from Molecular & Cellular Probes
#678
of 854 outputs
Outputs of similar age
#147,749
of 187,967 outputs
Outputs of similar age from Molecular & Cellular Probes
#2
of 2 outputs
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So far Altmetric has tracked 854 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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