Title |
Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens
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Published in |
BMC Genomics, July 2009
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DOI | 10.1186/1471-2164-10-302 |
Pubmed ID | |
Authors |
Paul Wilkinson, Nicholas R Waterfield, Lisa Crossman, Craig Corton, Maria Sanchez-Contreras, Isabella Vlisidou, Andrew Barron, Alexandra Bignell, Louise Clark, Douglas Ormond, Matthew Mayho, Nathalie Bason, Frances Smith, Mark Simmonds, Carol Churcher, David Harris, Nicholas R Thompson, Michael Quail, Julian Parkhill, Richard H ffrench-Constant |
Abstract |
The Gram-negative bacterium Photorhabdus asymbiotica (Pa) has been recovered from human infections in both North America and Australia. Recently, Pa has been shown to have a nematode vector that can also infect insects, like its sister species the insect pathogen P. luminescens (Pl). To understand the relationship between pathogenicity to insects and humans in Photorhabdus we have sequenced the complete genome of Pa strain ATCC43949 from North America. This strain (formerly referred to as Xenorhabdus luminescens strain 2) was isolated in 1977 from the blood of an 80 year old female patient with endocarditis, in Maryland, USA. Here we compare the complete genome of Pa ATCC43949 with that of the previously sequenced insect pathogen P. luminescens strain TT01 which was isolated from its entomopathogenic nematode vector collected from soil in Trinidad and Tobago. |
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