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Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men 1 , 2

Overview of attention for article published in American Journal of Clinical Nutrition, July 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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Title
Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men 1 , 2
Published in
American Journal of Clinical Nutrition, July 2016
DOI 10.3945/ajcn.116.133561
Pubmed ID
Authors

Kevin D Hall, Kong Y Chen, Juen Guo, Yan Y Lam, Rudolph L Leibel, Laurel Es Mayer, Marc L Reitman, Michael Rosenbaum, Steven R Smith, B Timothy Walsh, Eric Ravussin

Abstract

The carbohydrate-insulin model of obesity posits that habitual consumption of a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia and results in adaptive suppression of energy expenditure (EE). Therefore, isocaloric exchange of dietary carbohydrate for fat is predicted to result in increased EE, increased fat oxidation, and loss of body fat. In contrast, a more conventional view that "a calorie is a calorie" predicts that isocaloric variations in dietary carbohydrate and fat will have no physiologically important effects on EE or body fat. We investigated whether an isocaloric low-carbohydrate ketogenic diet (KD) is associated with changes in EE, respiratory quotient (RQ), and body composition. Seventeen overweight or obese men were admitted to metabolic wards, where they consumed a high-carbohydrate baseline diet (BD) for 4 wk followed by 4 wk of an isocaloric KD with clamped protein. Subjects spent 2 consecutive days each week residing in metabolic chambers to measure changes in EE (EEchamber), sleeping EE (SEE), and RQ. Body composition changes were measured by dual-energy X-ray absorptiometry. Average EE during the final 2 wk of the BD and KD periods was measured by doubly labeled water (EEDLW). Subjects lost weight and body fat throughout the study corresponding to an overall negative energy balance of ∼300 kcal/d. Compared with BD, the KD coincided with increased EEchamber (57 ± 13 kcal/d, P = 0.0004) and SEE (89 ± 14 kcal/d, P < 0.0001) and decreased RQ (-0.111 ± 0.003, P < 0.0001). EEDLW increased by 151 ± 63 kcal/d (P = 0.03). Body fat loss slowed during the KD and coincided with increased protein utilization and loss of fat-free mass. The isocaloric KD was not accompanied by increased body fat loss but was associated with relatively small increases in EE that were near the limits of detection with the use of state-of-the-art technology. This trial was registered at clinicaltrials.gov as NCT01967563.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 791 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
United Kingdom 1 <1%
Germany 1 <1%
Brazil 1 <1%
Unknown 784 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 166 21%
Student > Master 132 17%
Researcher 68 9%
Student > Ph. D. Student 57 7%
Other 42 5%
Other 118 15%
Unknown 208 26%
Readers by discipline Count As %
Nursing and Health Professions 130 16%
Medicine and Dentistry 119 15%
Biochemistry, Genetics and Molecular Biology 74 9%
Agricultural and Biological Sciences 74 9%
Sports and Recreations 63 8%
Other 94 12%
Unknown 237 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 697. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2024.
All research outputs
#29,934
of 25,519,924 outputs
Outputs from American Journal of Clinical Nutrition
#105
of 12,645 outputs
Outputs of similar age
#543
of 371,107 outputs
Outputs of similar age from American Journal of Clinical Nutrition
#2
of 95 outputs
Altmetric has tracked 25,519,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,645 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.