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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
|
|---|---|
| Published in |
Nature Genetics, September 2012
|
| DOI | 10.1038/ng.2387 |
| Pubmed ID | |
| Authors |
Sharon J Diskin, Mario Capasso, Robert W Schnepp, Kristina A Cole, Edward F Attiyeh, Cuiping Hou, Maura Diamond, Erica L Carpenter, Cynthia Winter, Hanna Lee, Jayanti Jagannathan, Valeria Latorre, Achille Iolascon, Hakon Hakonarson, Marcella Devoto, John M Maris |
| Abstract |
Neuroblastoma is a cancer of the sympathetic nervous system that accounts for approximately 10% of all pediatric oncology deaths. Here, we report a genome-wide association study of 2,817 neuroblastoma cases and 7,473 controls. We identified two new associations at 6q16, the first within HACE1 (rs4336470; combined P=2.7×10(-11); odds ratio 1.26, 95% confidence interval (CI) 1.18-1.35) and the second within LIN28B (rs17065417; combined P=1.2×10(-8); odds ratio 1.38, 95% CI 1.23-1.54). Expression of LIN28B and let-7 miRNA correlated with rs17065417 genotype in neuroblastoma cell lines, and we observed significant growth inhibition upon depletion of LIN28B, specifically in neuroblastoma cells that were homozygous for the risk allele. Low HACE1 and high LIN28B expression in diagnostic primary neuroblastomas were associated with worse overall survival (P=0.008 and 0.014, respectively). Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 5 | 45% |
| United States | 2 | 18% |
| Switzerland | 1 | 9% |
| United Kingdom | 1 | 9% |
| Unknown | 2 | 18% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Scientists | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 144 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 22% |
| Student > Ph. D. Student | 28 | 19% |
| Student > Master | 17 | 11% |
| Student > Bachelor | 15 | 10% |
| Student > Postgraduate | 12 | 8% |
| Other | 19 | 13% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 28% |
| Biochemistry, Genetics and Molecular Biology | 32 | 21% |
| Medicine and Dentistry | 32 | 21% |
| Psychology | 3 | 2% |
| Neuroscience | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 31 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2018.
All research outputs
#751,528
of 22,675,759 outputs
Outputs from Nature Genetics
#1,413
of 7,175 outputs
Outputs of similar age
#4,208
of 170,475 outputs
Outputs of similar age from Nature Genetics
#5
of 77 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,175 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,475 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.