| Title |
Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
|
|---|---|
| Published in |
Pharmaceutical Research, July 2016
|
| DOI | 10.1007/s11095-016-1979-0 |
| Pubmed ID | |
| Authors |
Sharan Bobbala, Sarah Hook |
| Abstract |
Modern vaccine design has moved away from attenuated or inactivated whole-pathogen vaccines to more pure and defined subunit vaccines. However subunit antigens have poor bioavailability and stability and lack immunogenicity. To overcome these issues subunit vaccines have to be administered in a suitable delivery system in combination with immune stimulants. Many different delivery systems have been developed and investigated each having different modes of action, for example increasing delivery and/or sustaining delivery of antigen to immune cells. In addition a number of different routes of immunization are possible and these can play a crucial role in determining the fate of an immune response. In this review the different strategies for the delivery of prophylactic and therapeutic subunit vaccines along with the impact of these on the immune responses generated are discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 98 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 20% |
| Student > Master | 13 | 13% |
| Student > Ph. D. Student | 10 | 10% |
| Researcher | 9 | 9% |
| Student > Postgraduate | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 30 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 17% |
| Agricultural and Biological Sciences | 13 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Chemistry | 7 | 7% |
| Engineering | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 34 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#3,301,450
of 24,784,213 outputs
Outputs from Pharmaceutical Research
#186
of 2,972 outputs
Outputs of similar age
#57,208
of 363,020 outputs
Outputs of similar age from Pharmaceutical Research
#8
of 47 outputs
Altmetric has tracked 24,784,213 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,972 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.