Title |
Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system
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Published in |
Reproductive Biology and Endocrinology, September 2012
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DOI | 10.1186/1477-7827-10-70 |
Pubmed ID | |
Authors |
Veronica Zaga-Clavellina, Martha Ruiz, Pilar Flores-Espinosa, Rodrigo Vega-Sanchez, Arturo Flores-Pliego, Guadalupe Estrada-Gutierrez, Irma Sosa-Gonzalez, Iyari Morales-Méndez, Mauricio Osorio-Caballero |
Abstract |
During intrauterine infection, amniochorionic membranes represent a mechanical and immunological barrier against dissemination of infection. Human beta defensins (HBD)-1, HBD-2, and HBD-3 are key elements of innate immunity that represent the first line of defense against different pathogen microorganisms associated with preterm labor. The aim of this work was to characterize the individual contribution of the amnion (AMN) and choriodecidua (CHD) regions to the secretion of HBD-1, HBD-2 and HBD-3, after stimulation with Candida albicans. |
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