Title |
Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion
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Published in |
Cognitive, Affective, & Behavioral Neuroscience, January 2012
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DOI | 10.3758/s13415-011-0078-2 |
Pubmed ID | |
Authors |
Henk van Steenbergen, Linda Booij, Guido P. H. Band, Bernhard Hommel, A. J. Willem van der Does |
Abstract |
Negative affect in healthy populations regulates the appraisal of demanding situations, which tunes subsequent effort mobilization and adjustments in cognitive control. In the present study, we hypothesized that dysphoria in depressed individuals similarly modulates this adaptation, possibly through a neural mechanism involving serotonergic regulation. We tested the effect of dysphoria induced by acute tryptophan depletion (ATD) in remitted depressed patients on conflict adaptation in a Simon task. ATD temporarily lowers the availability of the serotonin precursor L-Tryptophan and is known to increase depressive symptoms in approximately half of remitted depressed participants. We found that depressive symptoms induced by ATD were associated with increased conflict adaptation. Our finding extends recent observations implying an important role of affect in regulating conflict-driven cognitive control. |
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Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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France | 3 | 3% |
Italy | 1 | <1% |
Israel | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 108 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 27 | 23% |
Researcher | 17 | 15% |
Student > Master | 16 | 14% |
Student > Bachelor | 14 | 12% |
Student > Doctoral Student | 7 | 6% |
Other | 21 | 18% |
Unknown | 15 | 13% |
Readers by discipline | Count | As % |
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Psychology | 60 | 51% |
Medicine and Dentistry | 10 | 9% |
Neuroscience | 8 | 7% |
Nursing and Health Professions | 2 | 2% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 11 | 9% |
Unknown | 24 | 21% |