| Title |
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
|
|---|---|
| Published in |
Journal of Neuroinflammation, June 2011
|
| DOI | 10.1186/1742-2094-8-64 |
| Pubmed ID | |
| Authors |
Pratibha V Nerurkar, Lisa M Johns, Lance M Buesa, Gideon Kipyakwai, Esther Volper, Ryuei Sato, Pranjal Shah, Domonkos Feher, Philip G Williams, Vivek R Nerurkar |
| Abstract |
The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabolic flux to the brain during overnutrition and obesity can orchestrate stress response, blood-brain barrier (BBB) disruption, recruitment of inflammatory immune cells from peripheral blood and microglial cells activation leading to neuroinflammation. The lack of an effective treatment for obesity-associated brain dysfunction may have far-reaching public health ramifications, urgently necessitating the identification of appropriate preventive and therapeutic strategies. The objective of our study was to investigate the neuroprotective effects of Momordica charantia (bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 22% |
| United States | 1 | 11% |
| Spain | 1 | 11% |
| Thailand | 1 | 11% |
| Canada | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 165 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 17% |
| Student > Master | 27 | 16% |
| Student > Bachelor | 27 | 16% |
| Researcher | 14 | 8% |
| Student > Postgraduate | 8 | 5% |
| Other | 30 | 18% |
| Unknown | 33 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 23% |
| Medicine and Dentistry | 17 | 10% |
| Neuroscience | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 14 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Other | 28 | 17% |
| Unknown | 45 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2022.
All research outputs
#4,369,297
of 25,371,288 outputs
Outputs from Journal of Neuroinflammation
#874
of 2,951 outputs
Outputs of similar age
#21,857
of 122,826 outputs
Outputs of similar age from Journal of Neuroinflammation
#7
of 20 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,826 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.