| Title |
Suppression of interleukin 17 production by Brazilian propolis in mice with collagen-induced arthritis
|
|---|---|
| Published in |
Inflammopharmacology, August 2011
|
| DOI | 10.1007/s10787-011-0088-2 |
| Pubmed ID | |
| Authors |
Mayuri Tanaka, Yoshihiro Okamoto, Takashi Fukui, Toshiyuki Masuzawa |
| Abstract |
Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propolis ethanolic extract on the pathogenesis of collagen-induced arthritis (CIA) in mice. Mice fed propolis exhibited significant lower clinical arthritis scores than those fed the control diet. To investigate the mechanism of the effect of propolis on CIA mice, we examined interleukin-17 (IL-17) production in CIA mice fed propolis using an enzyme-linked immunospot assay and flow cytometric analysis. The numbers of IL-17-producing cells in the CIA mice fed propolis were significantly decreased. To determine direct influence of propolis on cytokine production, splenocytes were stimulated with phorbol myristate acetate in the presence of propolis extract in vitro. Concentration-dependent declines in IL-17 expression were observed by ELISA and real-time PCR methods. We further found that propolis significantly inhibited the differentiation of Th17 cells from murine splenocytes in a concentration-dependent manner. Taken together, our results may provide a new light on the potential mechanism of the immunosuppressive and anti-inflammatory effects of propolis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 18% |
| Researcher | 5 | 13% |
| Student > Doctoral Student | 5 | 13% |
| Student > Master | 4 | 10% |
| Student > Postgraduate | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 28% |
| Agricultural and Biological Sciences | 6 | 15% |
| Chemistry | 3 | 8% |
| Environmental Science | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 6 | 15% |
| Unknown | 12 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2014.
All research outputs
#18,314,922
of 22,678,224 outputs
Outputs from Inflammopharmacology
#367
of 530 outputs
Outputs of similar age
#102,249
of 124,010 outputs
Outputs of similar age from Inflammopharmacology
#3
of 3 outputs
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