| Title |
Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
|
|---|---|
| Published in |
European Journal of Epidemiology, August 2012
|
| DOI | 10.1007/s10654-012-9728-0 |
| Pubmed ID | |
| Authors |
Timo E. Strandberg, Arto Y. Strandberg, Outi Saijonmaa, Reijo S. Tilvis, Kaisu H. Pitkälä, Frej Fyhrquist |
| Abstract |
There are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1-98, 99-196, 197-490, >490 g/week) has been repeatedly assessed until old age. In 2002/2003, leukocyte telomere length (LTL) and the proportion of short telomeres (less than 5 kilobases) were measured in a random subcohort of 499 men (mean age 76 years) using the Southern blot. Age-adjusted mean LTL in the 5 midlife alcohol consumption groups were 8.33, 8.24, 8.12, 8.13, and 7.87 kilobases, respectively (P < 0.001). The respective proportions (%) for short telomeres were 11.24, 11.52, 11.89, 12.08, and 13.47 (P = 0.004). The differences remained after further adjustments (ever smoking, body mass index, cholesterol, perceived fitness) for LTL (P = 0.03) and tended to remain for proportion of short telomeres (P = 0.07). Neither LTL, nor proportion of short telomeres, were associated with contemporary alcohol consumption groups in old age. Even minor alcohol consumption in midlife was significantly associated with shorter telomere length in old age. The differences represent an up to 10 year gap in biological age between zero and highest consumption. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 67 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 21% |
| Researcher | 11 | 16% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Student > Bachelor | 5 | 7% |
| Other | 13 | 19% |
| Unknown | 11 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 25% |
| Agricultural and Biological Sciences | 10 | 15% |
| Biochemistry, Genetics and Molecular Biology | 9 | 13% |
| Psychology | 8 | 12% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 16 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
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#13,367,517
of 22,678,224 outputs
Outputs from European Journal of Epidemiology
#1,196
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#92,320
of 166,798 outputs
Outputs of similar age from European Journal of Epidemiology
#9
of 14 outputs
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