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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology
|
|---|---|
| Published in |
Immunity, September 2012
|
| DOI | 10.1016/j.immuni.2012.06.014 |
| Pubmed ID | |
| Authors |
Aisling O’Hara Hall, Daniel P. Beiting, Cristina Tato, Beena John, Guillaume Oldenhove, Claudia Gonzalez Lombana, Gretchen Harms Pritchard, Jonathan S. Silver, Nicolas Bouladoux, Jason S. Stumhofer, Tajie H. Harris, John Grainger, Elia D. Tait Wojno, Sagie Wagage, David S. Roos, Philip Scott, Laurence A. Turka, Sara Cherry, Steven L. Reiner, Daniel Cua, Yasmine Belkaid, M. Merle Elloso, Christopher A. Hunter |
| Abstract |
Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 307 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| United Kingdom | 2 | <1% |
| Chile | 1 | <1% |
| Sweden | 1 | <1% |
| France | 1 | <1% |
| Mexico | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 295 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 90 | 29% |
| Researcher | 73 | 24% |
| Student > Master | 26 | 8% |
| Student > Bachelor | 24 | 8% |
| Other | 13 | 4% |
| Other | 46 | 15% |
| Unknown | 35 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 105 | 34% |
| Immunology and Microbiology | 85 | 28% |
| Medicine and Dentistry | 35 | 11% |
| Biochemistry, Genetics and Molecular Biology | 25 | 8% |
| Veterinary Science and Veterinary Medicine | 3 | <1% |
| Other | 14 | 5% |
| Unknown | 40 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#4,760,001
of 25,373,627 outputs
Outputs from Immunity
#2,534
of 4,815 outputs
Outputs of similar age
#33,639
of 187,194 outputs
Outputs of similar age from Immunity
#19
of 42 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,815 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,194 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.