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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
|
|---|---|
| Published in |
Blood, September 2012
|
| DOI | 10.1182/blood-2012-02-412726 |
| Pubmed ID | |
| Authors |
Mathias Gelderblom, Anna Weymar, Christian Bernreuther, Joachim Velden, Priyadharshini Arunachalam, Karin Steinbach, Ellen Orthey, Thiruma V. Arumugam, Frank Leypoldt, Olga Simova, Vivien Thom, Manuel A. Friese, Immo Prinz, Christoph Hölscher, Markus Glatzel, Thomas Korn, Christian Gerloff, Eva Tolosa, Tim Magnus |
| Abstract |
The devastating effect of ischemic stroke is attenuated in mice lacking conventional and unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral ischemia. We explored the functional role of αβ and γδ T cells in a murine model of stroke and distinguished 2 different T cell-dependent proinflammatory pathways in ischemia-reperfusion injury. IFN-γ produced by CD4(+) T cells induced TNF-α production in macrophages, whereas IL-17A secreted by γδ T cells led to neutrophil recruitment. The synergistic effect of TNF-α and IL-17A on astrocytes resulted in enhanced secretion of CXCL-1, a neutrophil chemoattractant. Application of an IL-17A-blocking antibody within 3 hours after stroke induction decreased infarct size and improved neurologic outcome in the murine model. In autoptic brain tissue of patients who had a stroke, we detected IL-17A-positive lymphocytes, suggesting that this aspect of the inflammatory cascade is also relevant in the human brain. We propose that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| Spain | 1 | <1% |
| India | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 217 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 19% |
| Student > Ph. D. Student | 41 | 18% |
| Student > Master | 25 | 11% |
| Student > Doctoral Student | 23 | 10% |
| Student > Bachelor | 15 | 7% |
| Other | 42 | 19% |
| Unknown | 34 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 19% |
| Neuroscience | 35 | 16% |
| Agricultural and Biological Sciences | 35 | 16% |
| Immunology and Microbiology | 25 | 11% |
| Biochemistry, Genetics and Molecular Biology | 17 | 8% |
| Other | 22 | 10% |
| Unknown | 46 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2021.
All research outputs
#1,482,760
of 25,371,288 outputs
Outputs from Blood
#1,237
of 33,239 outputs
Outputs of similar age
#9,005
of 187,180 outputs
Outputs of similar age from Blood
#7
of 320 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,239 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,180 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 320 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.