| Title |
Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing salpingo-oophorectomy
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, March 2011
|
| DOI | 10.1007/s10549-011-1423-4 |
| Pubmed ID | |
| Authors |
Ingrid E. Fakkert, Liesbeth Jansen, Kees Meijer, Theo Kok, Jan C. Oosterwijk, Marian J. E. Mourits, Geertruida H. de Bock |
| Abstract |
Breast cancer screening is offered to BRCA1 and BRCA2 mutation carriers from the age of 25 years because of their increased risk of breast cancer. As ovarian cancer screening is not effective, risk-reducing salpinghooophorectomy (RRSO) is offered after child bearing age. RRSO before menopause reduces the breast cancer risk as well as breast density. It can be questioned whether after premenopausal RRSO, the intensive breast cancer screening program needs modification. We evaluated the effectiveness of breast cancer screening by clinical breast examination (CBE), mammography, and MRI in a population of 88 BRCA1 and 51 BRCA2 mutation carriers who had RRSO before the age of 52. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each screening modality. During 422 women years, 14 breast cancers were diagnosed; 2 prevalent, 10 screen detected and 2 interval breast cancers (12 in BRCA1 and 2 in BRCA2 mutation carriers). Sensitivity, specificity, PPV, and NPV for the combined screening were 85.7%, 97.6%, 30.0%, and 99.8%, respectively. No tumors were found with CBE, MRI had a sensitivity of 60.0% and mammography of 55.6%. Off all the tumors, 60% were node positive. Effectiveness of CBE and mammography was comparable to earlier findings. MRI screening seemed less effective than earlier findings. After RRSO, the breast cancer risk in BRCA1 and BRCA2 mutation carriers is still high enough to justify intensive breast cancer screening with MRI and mammography. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 22% |
| Student > Ph. D. Student | 6 | 16% |
| Student > Bachelor | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Other | 8 | 22% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 41% |
| Agricultural and Biological Sciences | 6 | 16% |
| Nursing and Health Professions | 3 | 8% |
| Unspecified | 2 | 5% |
| Computer Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2012.
All research outputs
#18,314,922
of 22,678,224 outputs
Outputs from Breast Cancer Research and Treatment
#3,681
of 4,617 outputs
Outputs of similar age
#96,017
of 108,737 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#46
of 54 outputs
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