Title |
Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells
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Published in |
BMC Complementary Medicine and Therapies, July 2012
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DOI | 10.1186/1472-6882-12-89 |
Pubmed ID | |
Authors |
Melody Saikali, Akram Ghantous, Racha Halawi, Salma N Talhouk, Najat A Saliba, Nadine Darwiche |
Abstract |
Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolated from Centaurea ainetensis, for their anti-tumor properties. We used the mouse epidermal JB6P + cells as a model for tumor promotion and cellular transformation. Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-κB transcription factors; therefore, we assessed how β-tan and Sal A modulate their signaling pathways in JB6P + cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 20% |
Student > Master | 5 | 20% |
Professor > Associate Professor | 4 | 16% |
Student > Ph. D. Student | 3 | 12% |
Professor | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 16% |
Medicine and Dentistry | 4 | 16% |
Chemistry | 4 | 16% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 4 | 16% |