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Properties of acyl modified poly(glycerol‐adipate) comb‐like polymers and their self‐assembly into nanoparticles

Overview of attention for article published in Journal of Polymer Science Part A: Polymer Chemistry, July 2016
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Title
Properties of acyl modified poly(glycerol‐adipate) comb‐like polymers and their self‐assembly into nanoparticles
Published in
Journal of Polymer Science Part A: Polymer Chemistry, July 2016
DOI 10.1002/pola.28215
Pubmed ID
Authors

Vincenzo Taresco, Jiraphong Suksiriworapong, Rhiannon Creasey, Jonathan C Burley, Giuseppe Mantovani, Cameron Alexander, Kevin Treacher, Jonathan Booth, Martin C Garnett

Abstract

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C4, C8, and C18 (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible polymers has been characterized through various techniques such as FT-IR, (1)H NMR, surface, thermal analysis, and their ability to self-assemble into colloidal structures was evaluated by using DLS. The highly tunable properties of PGA reported herein demonstrate a biodegradable polymer platform, ideal for engineering solid dispersions, nanoemulsions, or nanoparticles for healthcare applications. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3267-3278.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 26%
Researcher 10 19%
Student > Master 5 9%
Professor > Associate Professor 4 8%
Student > Doctoral Student 3 6%
Other 5 9%
Unknown 12 23%
Readers by discipline Count As %
Chemistry 14 26%
Pharmacology, Toxicology and Pharmaceutical Science 12 23%
Materials Science 5 9%
Engineering 2 4%
Medicine and Dentistry 1 2%
Other 2 4%
Unknown 17 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2016.
All research outputs
#20,125,075
of 25,604,262 outputs
Outputs from Journal of Polymer Science Part A: Polymer Chemistry
#5,174
of 5,742 outputs
Outputs of similar age
#272,739
of 371,392 outputs
Outputs of similar age from Journal of Polymer Science Part A: Polymer Chemistry
#28
of 64 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,742 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,392 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.