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Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle

Overview of attention for article published in Physiology & Behavior, June 2004
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Title
Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle
Published in
Physiology & Behavior, June 2004
DOI 10.1016/j.physbeh.2004.03.004
Pubmed ID
Authors

Thomas H.J Burne, François Féron, Jillanne Brown, Darryl W Eyles, John J McGrath, Alan Mackay-Sim

Abstract

There is growing evidence that 1,25-dihydroxyvitamin D3 is involved in normal brain development. The aim of this study was to examine the impact of prenatal and postnatal hypovitaminosis D on prepulse inhibition (PPI) of acoustic startle in adult rats. We compared six groups of rats: control rats with normal vitamin D throughout life and normal litter size (Litter); control rats with normal vitamin D but with a reduced litter size of two (Control); offspring from reduced litters of vitamin D deplete mothers who were repleted at birth (Birth), repleted at weaning (Weaning) or remained on a deplete diet until 10 weeks of age (Life); or control rats that were placed on a vitamin D-deficient diet from 5 to 10 weeks of age (Adult). All rats were tested in acoustic startle chambers at 5 and 10 weeks of age for acoustic startle responses and for PPI. There were no significant group differences at 5 weeks of age on the acoustic startle response or on PPI. At 10 weeks of age, rats in the Life group only had impaired PPI despite having normal acoustic startle responses. We conclude that combined prenatal and chronic postnatal hypovitaminosis D, but not early life hypovitaminosis D, alters PPI.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Student > Ph. D. Student 5 19%
Researcher 3 11%
Student > Bachelor 2 7%
Professor > Associate Professor 2 7%
Other 3 11%
Unknown 6 22%
Readers by discipline Count As %
Medicine and Dentistry 6 22%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 2 7%
Nursing and Health Professions 2 7%
Psychology 2 7%
Other 4 15%
Unknown 6 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2015.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Physiology & Behavior
#3,320
of 5,537 outputs
Outputs of similar age
#55,864
of 62,304 outputs
Outputs of similar age from Physiology & Behavior
#8
of 11 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,304 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.