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Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

Overview of attention for article published in Mammalian Genome, September 2012
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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2 X users
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1 Wikipedia page

Citations

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129 Dimensions

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107 Mendeley
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2 CiteULike
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Title
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project
Published in
Mammalian Genome, September 2012
DOI 10.1007/s00335-012-9418-y
Pubmed ID
Authors

Abdel Ayadi, Marie-Christine Birling, Joanna Bottomley, James Bussell, Helmut Fuchs, Martin Fray, Valérie Gailus-Durner, Simon Greenaway, Richard Houghton, Natasha Karp, Sophie Leblanc, Christoph Lengger, Holger Maier, Ann-Marie Mallon, Susan Marschall, David Melvin, Hugh Morgan, Guillaume Pavlovic, Ed Ryder, William C. Skarnes, Mohammed Selloum, Ramiro Ramirez-Solis, Tania Sorg, Lydia Teboul, Laurent Vasseur, Alison Walling, Tom Weaver, Sara Wells, Jacqui K. White, Allan Bradley, David J. Adams, Karen P. Steel, Martin Hrabě de Angelis, Steve D. Brown, Yann Herault

Abstract

Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with the aim to deliver a comprehensive assessment of phenotypes or to screen for robust indicators of diseases in mouse mutants. They both took advantage of available mouse mutant lines but predominantly of the embryonic stem (ES) cells resources derived from the European Conditional Mouse Mutagenesis programme (EUCOMM) and the Knockout Mouse Project (KOMP) to produce and study 799 mouse models that were systematically analysed with a comprehensive set of physiological and behavioural paradigms. They captured more than 400 variables and an additional panel of metadata describing the conditions of the tests. All the data are now available through EuroPhenome database (www.europhenome.org) and the WTSI mouse portal (http://www.sanger.ac.uk/mouseportal/), and the corresponding mouse lines are available through the European Mouse Mutant Archive (EMMA), the International Knockout Mouse Consortium (IKMC), or the Knockout Mouse Project (KOMP) Repository. Overall conclusions from both studies converged, with at least one phenotype scored in at least 80% of the mutant lines. In addition, 57% of the lines were viable, 13% subviable, 30% embryonic lethal, and 7% displayed fertility impairments. These efforts provide an important underpinning for a future global programme that will undertake the complete functional annotation of the mammalian genome in the mouse model.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 2%
France 2 2%
Hungary 1 <1%
Germany 1 <1%
Sweden 1 <1%
United States 1 <1%
Unknown 99 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 27%
Student > Ph. D. Student 19 18%
Other 12 11%
Student > Bachelor 11 10%
Student > Doctoral Student 5 5%
Other 15 14%
Unknown 16 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 36%
Biochemistry, Genetics and Molecular Biology 25 23%
Medicine and Dentistry 10 9%
Neuroscience 4 4%
Computer Science 3 3%
Other 9 8%
Unknown 18 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2013.
All research outputs
#6,381,374
of 22,678,224 outputs
Outputs from Mammalian Genome
#281
of 1,124 outputs
Outputs of similar age
#46,045
of 168,840 outputs
Outputs of similar age from Mammalian Genome
#5
of 16 outputs
Altmetric has tracked 22,678,224 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,124 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.