Title |
Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation
|
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Published in |
Current Allergy and Asthma Reports, July 2016
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DOI | 10.1007/s11882-016-0634-5 |
Pubmed ID | |
Authors |
Shigeharu Ueki, Takahiro Tokunaga, Shigeharu Fujieda, Kohei Honda, Makoto Hirokawa, Lisa A. Spencer, Peter F. Weller |
Abstract |
The traditional paradigm of eosinophils as end-stage damaging cells has mainly relied on their release of cytotoxic proteins. Cytokine-induced cell survival and secretion of granular contents from tissue-dwelling eosinophil are thought to be important mechanisms for eosinophilic inflammatory disorders, although the occurrence of cytolysis and its products (i.e., free extracellular granules) has been observed in affected lesions. Recent evidence indicates that activated eosinophils can exhibit a non-apoptotic cell death pathway, namely extracellular trap cell death (ETosis) that mediates the eosinophil cytolytic degranulation. Here, we discuss the current concept of eosinophil ETosis which provides a new look at eosinophilic inflammation. Lessons from eosinophilic chronic rhinosinusitis revealed that ETosis-derived DNA traps, composed of stable web-like chromatin, contribute to the properties of highly viscous eosinophilic mucin and impairments in its clearance. Intact granules entrapped in DNA traps are causing long-lasting inflammation but also might have immunoregulatory roles. Eosinophils possess a way to have post-postmortem impacts on innate immunity, local immune response, sterile inflammation, and tissue damage. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Romania | 1 | 20% |
Australia | 1 | 20% |
United Kingdom | 1 | 20% |
France | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 89 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 16% |
Researcher | 14 | 16% |
Student > Bachelor | 11 | 12% |
Student > Doctoral Student | 9 | 10% |
Student > Master | 9 | 10% |
Other | 14 | 16% |
Unknown | 18 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 27% |
Immunology and Microbiology | 15 | 17% |
Biochemistry, Genetics and Molecular Biology | 14 | 16% |
Agricultural and Biological Sciences | 13 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 2 | 2% |
Unknown | 20 | 22% |