| Title |
Immune response and immunopathology during toxoplasmosis
|
|---|---|
| Published in |
Seminars in Immunopathology, September 2012
|
| DOI | 10.1007/s00281-012-0339-3 |
| Pubmed ID | |
| Authors |
Christopher D. Dupont, David A. Christian, Christopher A. Hunter |
| Abstract |
Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is able to infect any warm-blooded vertebrate host. In addition to its importance to public health, several inherent features of the biology of T. gondii have made it an important model organism to study host-pathogen interactions. One factor is the genetic tractability of the parasite, which allows studies on the microbial factors that affect virulence and allows the development of tools that facilitate immune studies. Additionally, mice are natural hosts for T. gondii, and the availability of numerous reagents to study the murine immune system makes this an ideal experimental system to understand the functions of cytokines and effector mechanisms involved in immunity to intracellular microorganisms. In this article, we will review current knowledge of the innate and adaptive immune responses required for resistance to toxoplasmosis, the events that lead to the development of immunopathology, and the natural regulatory mechanisms that limit excessive inflammation during this infection. |
Mendeley readers
The data shown below were compiled from readership statistics for 321 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 316 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 56 | 17% |
| Student > Ph. D. Student | 49 | 15% |
| Student > Master | 46 | 14% |
| Researcher | 29 | 9% |
| Student > Doctoral Student | 20 | 6% |
| Other | 48 | 15% |
| Unknown | 73 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 21% |
| Immunology and Microbiology | 50 | 16% |
| Biochemistry, Genetics and Molecular Biology | 35 | 11% |
| Medicine and Dentistry | 34 | 11% |
| Veterinary Science and Veterinary Medicine | 13 | 4% |
| Other | 36 | 11% |
| Unknown | 85 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2020.
All research outputs
#7,173,418
of 22,678,224 outputs
Outputs from Seminars in Immunopathology
#213
of 544 outputs
Outputs of similar age
#53,621
of 169,032 outputs
Outputs of similar age from Seminars in Immunopathology
#6
of 10 outputs
Altmetric has tracked 22,678,224 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 544 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,032 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.