| Title |
Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years
|
|---|---|
| Published in |
European Radiology, July 2016
|
| DOI | 10.1007/s00330-016-4485-1 |
| Pubmed ID | |
| Authors |
René-Maxime Gracien, Lucas Nürnberger, Pavel Hok, Stephanie-Michelle Hof, Sarah C. Reitz, Udo Rüb, Helmuth Steinmetz, Rüdiger Hilker-Roggendorf, Johannes C. Klein, Ralf Deichmann, Simon Baudrexel |
| Abstract |
T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. T1 mapping was performed in 17 healthy subjects (range 51-77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations. • T1 mapping is sensitive to age-related microstructural changes in a longitudinal setting. • T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. • The rate of T1 reduction was more prominent in subjects with higher age. • These changes most likely reflect decreasing cortical water and increasing iron concentrations. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| United Kingdom | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Researcher | 10 | 21% |
| Student > Master | 5 | 10% |
| Unspecified | 3 | 6% |
| Student > Postgraduate | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 12 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 19% |
| Medicine and Dentistry | 7 | 15% |
| Engineering | 4 | 8% |
| Unspecified | 3 | 6% |
| Physics and Astronomy | 2 | 4% |
| Other | 9 | 19% |
| Unknown | 14 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2022.
All research outputs
#4,716,310
of 23,243,271 outputs
Outputs from European Radiology
#597
of 4,210 outputs
Outputs of similar age
#83,368
of 356,393 outputs
Outputs of similar age from European Radiology
#5
of 57 outputs
Altmetric has tracked 23,243,271 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,210 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 85% of its peers.
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