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The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival

Overview of attention for article published in International Journal of Cancer, February 2012
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Title
The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival
Published in
International Journal of Cancer, February 2012
DOI 10.1002/ijc.27420
Pubmed ID
Authors

Aaron P. Thrift, Christina M. Nagle, Paul P. Fahey, Anne Russell, Bernard M. Smithers, David I. Watson, David C. Whiteman, for the Australian Cancer Study Clinical Follow‐Up Study

Abstract

Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based case-control study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming<1 drink/week, the HRs for those with average consumption of 7-20 drinks/week or ≥21 drinks/week were 2.21 (95% CI=1.27-3.84) and 2.08 (95% CI=1.18-3.69), respectively. There was a suggestion of worse survival among current smokers (HR=1.42, 95% CI=0.89-2.28); however, the risk of early death was greatest among current smokers who reported regularly (≥7 drinks/week) consuming alcohol (HR=3.84, 95% CI=2.02-7.32). Other lifestyle factors putatively associated with risk of developing ESCC were not associated with survival. In addition to increasing disease risk, heavy alcohol consumption may be independently associated with worse survival among patients with ESCC. Future clinical follow-up studies should consider alcohol as a potential prognosticator, in addition to known clinicopathologic factors.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Ph. D. Student 6 15%
Other 4 10%
Student > Bachelor 4 10%
Student > Master 3 8%
Other 6 15%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 15 38%
Agricultural and Biological Sciences 2 5%
Engineering 2 5%
Psychology 2 5%
Nursing and Health Professions 1 3%
Other 3 8%
Unknown 14 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2012.
All research outputs
#20,038,510
of 24,629,540 outputs
Outputs from International Journal of Cancer
#10,766
of 12,093 outputs
Outputs of similar age
#124,664
of 159,269 outputs
Outputs of similar age from International Journal of Cancer
#75
of 96 outputs
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