Title |
Heterodinuclear ruthenium( ii )–cobalt( iii ) complexes as models for a new approach to selective cancer treatment
|
---|---|
Published in |
Dalton Transactions: An International Journal of Inorganic Chemistry, January 2012
|
DOI | 10.1039/c2dt31986a |
Pubmed ID | |
Authors |
Alan M. Downward, Reuben T. Jane, Matthew I. J. Polson, Evan G. Moore, Richard M. Hartshorn |
Abstract |
Heterodinuclear ruthenium(II)-cobalt(III) complexes have been prepared as part of investigations into a new approach to selective cancer treatment. A cobalt(III) centre bearing amine ligands, which serve as models for cytotoxic nitrogen mustard ligands, is connected by a bridging ligand to a ruthenium(II)-polypyridyl moiety. Upon excitation of the ruthenium centre by visible light, electron transfer to the cobalt(III) centre results in reduction to cobalt(II) and consequent release of its ligands. We have synthesised several such structures and demonstrated their ability to release ligands upon excitation of the ruthenium centre by visible light. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Japan | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 22% |
Professor | 4 | 22% |
Student > Ph. D. Student | 3 | 17% |
Student > Master | 3 | 17% |
Researcher | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 10 | 56% |
Agricultural and Biological Sciences | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Physics and Astronomy | 1 | 6% |
Unknown | 3 | 17% |