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Genome-wide Association Study of Periodontal Pathogen Colonization

Overview of attention for article published in Critical Reviews in Oral Biology & Medicine, June 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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3 X users
wikipedia
1 Wikipedia page

Citations

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125 Dimensions

Readers on

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121 Mendeley
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Title
Genome-wide Association Study of Periodontal Pathogen Colonization
Published in
Critical Reviews in Oral Biology & Medicine, June 2012
DOI 10.1177/0022034512447951
Pubmed ID
Authors

K. Divaris, K.L. Monda, K.E. North, A.F. Olshan, E.M. Lange, K. Moss, S.P. Barros, J.D. Beck, S. Offenbacher

Abstract

Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. We conducted a genome-wide association (GWA) study among 1,020 white participants of the Atherosclerosis Risk in Communities Study, whose periodontal diagnosis ranged from healthy to severe chronic periodontitis, and for whom "checkerboard" DNA-DNA hybridization quantification of 8 periodontal pathogens was performed. We examined 3 traits: "high red" and "high orange" bacterial complexes, and "high" Aggregatibacter actinomycetemcomitans (Aa) colonization. Genotyping was performed on the Affymetrix 6.0 platform. Imputation to 2.5 million markers was based on HapMap II-CEU, and a multiple-test correction was applied (genome-wide threshold of p < 5 × 10(-8)). We detected no genome-wide significant signals. However, 13 loci, including KCNK1, FBXO38, UHRF2, IL33, RUNX2, TRPS1, CAMTA1, and VAMP3, provided suggestive evidence (p < 5 × 10(-6)) of association. All associations reported for "red" and "orange" complex microbiota, but not for Aa, had the same effect direction in a second sample of 123 African-American participants. None of these polymorphisms was associated with periodontitis diagnosis. Investigations replicating these findings may lead to an improved understanding of the complex nature of host-microbiome interactions that characterizes states of health and disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 13%
Researcher 16 13%
Student > Master 16 13%
Student > Bachelor 12 10%
Other 9 7%
Other 30 25%
Unknown 22 18%
Readers by discipline Count As %
Medicine and Dentistry 37 31%
Agricultural and Biological Sciences 20 17%
Biochemistry, Genetics and Molecular Biology 17 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Nursing and Health Professions 2 2%
Other 14 12%
Unknown 28 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2021.
All research outputs
#7,262,995
of 25,540,105 outputs
Outputs from Critical Reviews in Oral Biology & Medicine
#1,208
of 3,872 outputs
Outputs of similar age
#49,455
of 181,356 outputs
Outputs of similar age from Critical Reviews in Oral Biology & Medicine
#9
of 23 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,872 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.