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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits
|
|---|---|
| Published in |
Nature Genetics, July 2016
|
| DOI | 10.1038/ng.3607 |
| Pubmed ID | |
| Abstract |
Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. We analyzed erythrocyte and WBC phenotypes in 52,531 individuals (37,775 of European ancestry, 11,589 African Americans, and 3,167 Hispanic Americans) from 16 population-based cohorts with Illumina HumanExome BeadChip genotypes. We then performed replication analyses of new discoveries in 18,018 European-American women and 5,261 Han Chinese. We identified and replicated four new erythrocyte trait-locus associations (CEP89, SHROOM3, FADS2, and APOE) and six new WBC loci for neutrophil count (S1PR4), monocyte count (BTBD8, NLRP12, and IL17RA), eosinophil count (IRF1), and total WBC count (MYB). The association of a rare missense variant in S1PR4 supports the role of sphingosine-1-phosphate signaling in leukocyte trafficking and circulating neutrophil counts. Loss-of-function experiments for S1pr4 in mouse and s1pr4 in zebrafish demonstrated phenotypes consistent with the association observed in humans and altered kinetics of neutrophil recruitment and resolution in response to tissue injury. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 23% |
| Russia | 1 | 8% |
| Spain | 1 | 8% |
| Netherlands | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 54% |
| Scientists | 6 | 46% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 21% |
| Researcher | 13 | 18% |
| Student > Postgraduate | 7 | 10% |
| Other | 4 | 6% |
| Professor | 4 | 6% |
| Other | 15 | 21% |
| Unknown | 13 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 32% |
| Agricultural and Biological Sciences | 12 | 17% |
| Medicine and Dentistry | 8 | 11% |
| Computer Science | 4 | 6% |
| Engineering | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#2,212,225
of 25,196,456 outputs
Outputs from Nature Genetics
#2,816
of 7,547 outputs
Outputs of similar age
#39,103
of 363,417 outputs
Outputs of similar age from Nature Genetics
#57
of 70 outputs
Altmetric has tracked 25,196,456 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,547 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,417 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.